Bicluster

Bicluster Motifs

Bicluster Genes

• Rv0213c
• Rv0217c
• Rv0219
• Rv0267
• Rv0371c
• Rv0607
• Rv0728c
• Rv0989c
• Rv1090
• Rv1735c
• Rv1801
• Rv1823
• Rv1878
• Rv1978
• Rv2143
• Rv2179c
• Rv2261c
• Rv2265
• Rv2282c
• Rv2285
• Rv2545
• Rv2897c
• Rv2985
• Rv3273
• Rv3643

Bicluster Conditions

• H37Rv.0.05..SDS.exposure.for.1h.rep.4
• H37Rv.0.05..SDS.exposure.for.1h.rep.6
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.5min.rep.1
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.5min.rep.4
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.20min.rep.1
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.20min.rep.4
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.40min.rep.3.x
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.40min.rep.4.x
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.1hr.rep.1
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.1hr.rep.4
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.2hrs.rep.1
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.16hrs.rep.1
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.16hrs.rep.3
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.16hrs.rep.4
• MTB.strain.1254.Ctrl.vs.1.0.mM.DETA.NO.40min.rep.1.x
• MTB.strain.1254.Ctrl.vs.1.0.mM.DETA.NO.40min.rep.3.x
• MTB.strain.1254.Ctrl.vs.1.0.mM.DETA.NO.40min.rep.4.x
• MTB.strain.1254.Ctrl.vs.5.0.mM.DETA.NO.40min.rep.1.x
• MTB.strain.1254.Ctrl.vs.5.0.mM.DETA.NO.40min.rep.4.x
• H37Rv.Ctrl.vs.0.05.mM.DETA.NO.40min.rep.1
• H37Rv.Ctrl.vs.0.05.mM.DETA.NO.40min.rep.3
• H37Rv.vs..H37Rv.SDS.treated.rep.1
• H37Rv.vs..H37Rv.SDS.treated.rep.2
• H37Rv.vs..H37Rv.SDS.treated.rep.3
• H37Rv.vs..H37Rv.SDS.treated.rep.4
• H37Rv.vs..H37Rv.SDS.treated.rep.5
• H37Rv.vs..H37Rv.SDS.treated.rep.6
• High.iron.wt.vs.low.iron.wt.1b
• High.iron.wt.vs.low.iron.wt.2a
• High.iron.wt.vs.low.iron.wt.2b
• High.iron.wt.vs.low.iron.wt.3b
• pH4.8vspH6.8..4h.
• pH4.8vspH6.8..4h.C
• pH4.8vspH6.8..5h.
• pH5.2vspH6.8..2h.
• pH5.2vspH6.8..5h.
• pH5.2vspH6.8..5.5h.
• pH5.2vspH6.8..10.5h.
• pH5.6vspH6.8..2h.
• pH5.6vspH6.8..2h.A
• pH5.6vspH6.8..4h.
• pH5.6vspH6.8..7h.
• pH5.6vspH6.8..11h.
• pH5.6vspH6.8..16h.
• X0.1mM.GSNOvsDMSO..4h
• X0.1mM.GSNO.DMSO..6h
• X0.1mM.GSNOvsDMSO..6h.
• X0.1mM.GSNOvsDMSO..6h.A
• X4mM.H2O2vsctrl..2h.
• X4mM.H2O2vsctrl..2h.A
• X4mM.H2O2vsctrl..4h.
• X4mM.H2O2vsctrl..4h.A
• H37Rv.diamide.1h.rep.1
• H37Rv.diamide.1h.rep.4
• H37Rv.wild.type.control.vs.0.05..SDS.for.60.min.rep.1
• H37Rv.wild.type.control.vs.0.05..SDS.for.60.min.rep.4
• H37Rv.wild.type.control.vs.0.05..SDS.for.60.min.rep.6
• H37Rv.wild.type.control.vs.5mM.Diamide.for.60.min.rep.1
• H37Rv.wild.type.control.vs.5mM.Diamide.for.60.min.rep.5
• X5ug.ml.KCN.vs.DMSO.6hrs.rep.2.x
• H37Rv.grown.in.7H9.vs.H37Rv.4hrs.after.infection.in.macrophages.rep.1
• H37Rv.grown.in.7H9.vs.H37Rv.4hrs.after.infection.in.macrophages.rep.5
• H37Rv.grown.in.7H9.vs.H37Rv.4hrs.after.infection.in.macrophages.rep.6
• H37Rv.grown.in.7H9.vs.H37Rv.24hrs.after.infection.in.macrophages.rep.2
• H37Rv.grown.in.7H9.vs.H37Rv.24hrs.after.infection.in.macrophages.rep.3
• CHP_25uM_1h_01
• MTB1254_SDS_90MIN_01
• MTB1254_SDS_90MIN_02
• MTB1254_SDS_90MIN_03
• MTB1254_SDS_90MIN_04
• SDS_3h_01
• SDS_60min_01
• Starvation_1254_24h_03
• Starvation_1254_24h_05
• Starvation_1254_24h_06
• Starvation_1254_24h_08
• Starvation_1254_6h_04
• Starvation_1254_6h_06
• Starvation_1254_6h_07
• Starvation_1254_6h_08
• Clinical.isolate.10514.01_Afri2.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.10517.01_Afri2.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.12954.03_Beijing.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.1500.03_Beijing.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.1797.03_EAI.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.1797.03_EAI.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.1934.03_Beijing.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.1934.03_Beijing.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.2169.99_Uganda.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.2191.99_Uganda.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.2191.99_Uganda.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.2333.99_Uganda.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.2333.99_Uganda.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.2336.02_Haarlem.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.4130.02_Haarlem.extra.vs.intracellular.in.activated.macrophages.rep.1
• Clinical.isolate.4850.03_EAI.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.947.01_EAI.extra.vs.intracellular.in.activated.macrophages.rep.2
• Clinical.isolate.9532.03_Haarlem.extra.vs.intracellular.in.activated.macrophages.rep.1
• H37Rv.extra.vs.intracellular.in.activated.macrophages.rep.1
• CDC1551.extra.vs.intracellular.in.activated.macrophages.rep.2
• MTB.in.Wild.type.macrophages.for.4hrs
• MTB.in.Wild.type.macrophages.for.24hrs
• MTB.in.Wild.type.macrophages.for.48hrs
• MTB.in.Wild.type.macrophages...IFNg.for.4hrs
• MTB.in.Wild.type.macrophages...IFNg.for.24hrs
• MTB.in.Wild.type.macrophages...IFNg.for.48hrs
• MTB.strain.1254.Ctrl.vs.0.005.mM.DETA.NO.40min.rep.4.y
• MTB.strain.1254.Ctrl.vs.0.05.mM.H202.40min.rep.2
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.40min.rep.6
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.40min.rep.7
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.4hrs.rep.2
• MTB.strain.1254.Ctrl.vs.0.5.mM.DETA.NO.4hrs.rep.3
• MTB.strain.1254.Ctrl.vs.0.5.mM.H202.40min.rep.6
• MTB.strain.1254.Ctrl.vs.1.0.mM.DETA.NO.40min.rep.1.y
• MTB.strain.1254.Ctrl.vs.1.0.mM.DETA.NO.40min.rep.4.y
• MTB.strain.1254.Ctrl.vs.200.mM.H202.40min.rep.1
• MTB.strain.1254.Ctrl.vs.200.mM.H202.40min.rep.2
• MTB.strain.1254.Ctrl.vs.200.mM.H202.40min.rep.4
• MTB.strain.1254.Ctrl.vs.200.mM.H202.40min.rep.5
• MTB.strain.1254.Ctrl.vs.200.mM.H202.40min.rep.6
• MTB.strain.1254.Ctrl.vs.5.0.mM.DETA.NO.40min.rep.1.y
• MTB.strain.1254.Ctrl.vs.5.0.mM.H202.40min.rep.1
• MTB.strain.1254.Ctrl.vs.5.0.mM.H202.40min.rep.4
• MTB.strain.1254.Ctrl.vs.5.0.mM.H202.40min.rep.5
• MTB.strain.1254.Ctrl.vs.50.0.mM.H202.40min.rep.5
• MTB.strain.1254.Ctrl.vs.50.0.mM.H202.40min.rep.6
• Russell_Lab_Spotted_Oligos_1.2..14.day.resting.macrophage.infection.2hr..rep.2..Russell_Lab_Spotted_Oligos_1.2..
• Russell_Lab_Spotted_Oligos_1.5..14.day.resting.macrophage.infection.Day.4..rep.1..Russell_Lab_Spotted_Oligos_1.5..
• Russell_Lab_Spotted_Oligos_1.9..14.day.resting.macrophage.infection.Day.8..rep.1..Russell_Lab_Spotted_Oligos_1.9..
• WT_140mM_NaCl_Rep2
• WT_140mM_NaCl_Rep4
• A00470_Q1_t30_diamide
• MTB1254.ethanol.vs..0.5.ug.ml.Tetracyclin.for.15.min.rep.1
• MTB1254.ethanol.vs..0.5.ug.ml.Tetracyclin.for.15.min.rep.4
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.15.min.rep.1
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.15.min.rep.3
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.15.min.rep.4
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.15.min.rep.1
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.15.min.rep.2
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.15.min.rep.3
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.15.min.rep.4
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.15.min.rep.1
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.15.min.rep.2
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.15.min.rep.3
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.15.min.rep.4
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.15.min.rep.1
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.15.min.rep.2
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.15.min.rep.3
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.15.min.rep.4
• MTB1254.ethanol.vs..0.5.ug.ml.Tetracyclin.for.30.min.rep.1
• MTB1254.ethanol.vs..0.5.ug.ml.Tetracyclin.for.30.min.rep.2
• MTB1254.ethanol.vs..0.5.ug.ml.Tetracyclin.for.30.min.rep.3
• MTB1254.ethanol.vs..0.5.ug.ml.Tetracyclin.for.30.min.rep.4
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.30.min.rep.1
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.30.min.rep.2
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.30.min.rep.3
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.30.min.rep.4
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.30.min.rep.1
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.30.min.rep.3
• MTB1254.ethanol.vs..5.0.ug.ml.Tetracyclin.for.30.min.rep.4
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.30.min.rep.1
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.30.min.rep.2
• MTB1254.ethanol.vs..25.ug.ml.Tetracyclin.for.30.min.rep.3
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.30.min.rep.1
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.30.min.rep.2
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.30.min.rep.3
• MTB1254.ethanol.vs..100.ug.ml.Tetracyclin.for.30.min.rep.4
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.2.hr.rep.1
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.2.hr.rep.2
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.2.hr.rep.3
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.2.hr.rep.4
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.24.hr.rep.1
• MTB1254.ethanol.vs..1.0.ug.ml.Tetracyclin.for.24.hr.rep.4
• MTB1254.control.vs..0.5.ug.ml.Streptomycin.for.15.min.rep.1
• MTB1254.control.vs..0.5.ug.ml.Streptomycin.for.15.min.rep.2
• MTB1254.control.vs..0.5.ug.ml.Streptomycin.for.15.min.rep.3
• MTB1254.control.vs..0.5.ug.ml.Streptomycin.for.15.min.rep.4
• MTB1254.control.vs..0.5.ug.ml.Streptomycin.for.15.min.rep.5
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.15.min.rep.1
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.15.min.rep.2
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.15.min.rep.3
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.15.min.rep.4
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.15.min.rep.5
• MTB1254.control.vs..5.0.ug.ml.Streptomycin.for.15.min.rep.1
• MTB1254.control.vs..5.0.ug.ml.Streptomycin.for.15.min.rep.2
• MTB1254.control.vs..5.0.ug.ml.Streptomycin.for.15.min.rep.3
• MTB1254.control.vs..5.0.ug.ml.Streptomycin.for.15.min.rep.4
• MTB1254.control.vs..25.ug.ml.Streptomycin.for.15.min.rep.1
• MTB1254.control.vs..25.ug.ml.Streptomycin.for.15.min.rep.2
• MTB1254.control.vs..25.ug.ml.Streptomycin.for.15.min.rep.4
• MTB1254.control.vs..100.ug.ml.Streptomycin.for.15.min.rep.1
• MTB1254.control.vs..100.ug.ml.Streptomycin.for.15.min.rep.2
• MTB1254.control.vs..100.ug.ml.Streptomycin.for.15.min.rep.3
• MTB1254.control.vs..100.ug.ml.Streptomycin.for.15.min.rep.4
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.2.hr..ref..rep.1
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.2.hr..ref..rep.2
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.2.hr..ref..rep.3
• MTB1254.control.vs..1.0.ug.ml.Streptomycin.for.24.hr..ref..rep.2
• MTB1254.ethanol.vs..0.5.ug.ml.Erythromycin.for.15.min.rep.1
• MTB1254.ethanol.vs..0.5.ug.ml.Erythromycin.for.15.min.rep.2
• MTB1254.ethanol.vs..0.5.ug.ml.Erythromycin.for.15.min.rep.3
• MTB1254.ethanol.vs..0.5.ug.ml.Erythromycin.for.15.min.rep.4
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.15.min.rep.1
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.15.min.rep.2
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.15.min.rep.3
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.15.min.rep.4
• MTB1254.ethanol.vs..5.0.ug.ml.Erythromycin.for.15.min.rep.1
• MTB1254.ethanol.vs..5.0.ug.ml.Erythromycin.for.15.min.rep.2
• MTB1254.ethanol.vs..5.0.ug.ml.Erythromycin.for.15.min.rep.3
• MTB1254.ethanol.vs..5.0.ug.ml.Erythromycin.for.15.min.rep.4
• MTB1254.ethanol.vs..25.ug.ml.Erythromycin.for.15.min.rep.2
• MTB1254.ethanol.vs..25.ug.ml.Erythromycin.for.15.min.rep.3
• MTB1254.ethanol.vs..100.ug.ml.Erythromycin.for.15.min.rep.1
• MTB1254.ethanol.vs..100.ug.ml.Erythromycin.for.15.min.rep.3
• MTB1254.ethanol.vs..0.5.ug.ml.Erythromycin.for.30.min.rep.1
• MTB1254.ethanol.vs..0.5.ug.ml.Erythromycin.for.30.min.rep.2
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.30.min.rep.1
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.30.min.rep.2
• MTB1254.ethanol.vs..1.0.ug.ml.Erythromycin.for.30.min.rep.3
• MTB1254.ethanol.vs..5.0.ug.ml.Erythromycin.for.30.min.rep.1
• MTB1254.ethanol.vs..5.0.ug.ml.Erythromycin.for.30.min.rep.2
• MTB1254.ethanol.vs..25.ug.ml.Erythromycin.for.30.min.rep.1
• MTB1254.ethanol.vs..100.ug.ml.Erythromycin.for.30.min.rep.1
• MTB1254.ethanol.vs..100.ug.ml.Erythromycin.for.30.min.rep.2
• MTB1254.ethanol.vs..100.ug.ml.Erythromycin.for.30.min.rep.3
• MTB1254.ethanol.vs..100.ug.ml.Erythromycin.for.30.min.rep.4
• MTB1254.control.vs..1.0.ug.ml.Erythromycin.for.2.hr..ref..rep.1
• MTB1254.control.vs..1.0.ug.ml.Erythromycin.for.2.hr..ref..rep.2
• MTB1254.control.vs..1.0.ug.ml.Erythromycin.for.2.hr..ref..rep.3
• MTB1254.control.vs..1.0.ug.ml.Erythromycin.for.2.hr..ref..rep.4
• X20ug.mL.Prcp.6776.DMSO..6h..1
• X20ug.mL.Procept6776vsDMSO..6h
• X20ug.mL.Prcp.6778.DMSO..6h..2
• X40ug.mLProcept6778vsDMSO.6hA
• X10ug.mL.PA.1vsDMSO..6h
• X10ug.mL.PA.1vsDMSO..6hA
• X10ug.mL.PA.1vsDMSO..6hB
• X10ug.mL.PA.21vsDMSO..6h
• X10ug.mL.PA.21vsDMSO..6hA
• X50ug.mL.PA.21vsDMSO..6h
• X0.2ug.mL.PA824.DMSO..6h..1
• X0.2ug.mL.PA824.DMSO..6h..2
• X0.4ug.mL.PA824.DMSO..6h..1
• X0.4ug.mL.PA824.DMSO..6h..2
• X0.4ug.mL.PA824.DMSO..6h..3
• X0.4ug.mL.PA824.DMSO..6h..4
• X2ug.mL.PA824.DMSO..6h..1
• X2ug.mL.PA824.DMSO..6h..2
• X5ug.mL.AmivsEtOH..6h
• X25ug.mL.AntimycinvsDMSO..6h
• X50ug.mLAntimycinAvsDMSO..6hA
• X50ug.mLAntimycinAvsDMSO..6hB
• X1mM.DTNBvsDMSO..6h
• X2mM.DTNBvsDMSO
• X5ug.mL.KCN.DMSO..6h..2
• X10ug.mL.methoxatinvsDMSO..6h.A
• X10ug.mLMethoxatinvsDMSO.6h
• X20ug.mL.methoxatinvsDMSO..6h
• X0.2ug.mL.RifvsDMSO..6h
• Rif.0.5ug.mL.vsDMSO.2.5h
• Rif.5ug.mL.vsDMSO.2.5h
• X0.1ug.mL.RifpvsEtOH..6h
• X0.1ug.mL.RifpvsEtOH..6hA
• X0.5ug.mLRifapentinevsEtOH.6h
• X0.5ug.mLRifapentinevsEtOH.6hA
• X30ug.mL.RoxvsEtOH..6h
• X5ug.mLStreptomycinvsEtOH.6h
• X5ug.mLStreptomycinvsEtOH.6hA
• X5ug.ml.KCN.vs.DMSO.6hrs.rep.2.y
• X0.2ug.ml.PA.824.vs.DMSO.6hrs.rep.1
• X0.2ug.ml.PA.824.vs.DMSO.6hrs.rep.2
• X0.4ug.ml.PA.824.vs.DMSO.6hrs.rep.2.x
• X0.4ug.ml.PA.824.vs.DMSO.6hrs.rep.3
• X0.4ug.ml.PA.824.vs.DMSO.6hrs.rep.4
• X2ug.ml.PA.824.vs.DMSO.6hrs.rep.2
• Tet_50ng_30M_01
• X0.4ug.ml.PA.824.vs.DMSO.6hrs.rep.2.y
• X2ug.ml.PA.824.vs.DMSO.6hrs.rep.1.y
• X10ug.ml.capreomycin.vs.Ethanol..6hrs
• X5ug.ml.Rifampicin.vs.DMSO.2.5hrs
• MTB.at.T0..biological.rep3
• MTB.at.T0..biological.rep4
• MTB.at.T30..biological.rep1
• MTB.at.T30..biological.rep2
• MTB.at.T60..biological.rep1
• MTB.at.T60..biological.rep2
• MTB.at.T180..biological.rep1
• MTB.at.T180..biological.rep2
• MTB.at.T180..biological.rep3
• MTB.at.T180..biological.rep4
• MTB.at.T360..biological.rep1
• MTB.at.T360..biological.rep2
• MTB.at.T360..biological.rep3
• MTB.at.T360..biological.rep4